Kaliakmanis, a seventh-round rookie from Rutgers, is in for Washington after Marcus Mariota was ruled out with a knee injury.

Week 4 brings with it a bevy of big injuries.

Indianapolis improved to 2-2 after Marcus Mariota's knee injury forced rookie Athan Kaliakmanis in at quarterback for Washington.

Barkley came up hobbling after a 6-yard run in Sunday's first quarter against the Rams.

Mariota was replaced by Kaliakmanis, a rookie seventh-round pick out of Rutgers.

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“I just know that I was the odd man out,” Payton said Monday night. “I never heard anything about it."

The 49ers rise to the top after upending the "superteam" Rams, while the Bears and Giants used big wins to move up in our rankings.