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HomeHealthAllogeneic NK cells with a bispecific innate cell engager in refractory relapsed lymphoma: a phase 1 trial

Allogeneic NK cells with a bispecific innate cell engager in refractory relapsed lymphoma: a phase 1 trial

Nature Medicine, Published online: 04 April 2025; doi:10.1038/s41591-025-03640-8

In this phase 1 trial, patients with heavily pretreated and refractory CD30+ lymphoma were safely treated with donor-cord-blood-derived NK cells that were precomplexed with the anti-CD30 and anti-CD16A bispecific antibody AFM13, showing encouraging preliminary clinical response rates.

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