Nature Medicine, Published online: 15 October 2025; doi:10.1038/s41591-025-04034-6
A multi-center, hospital-based observational study in India evaluated the effectiveness of Rotavac, a locally produced rotavirus vaccine, against laboratory-confirmed rotavirus gastroenteritis in children under 5 years of age. Vaccine effectiveness was stratified by age and viral genotype, and vaccine impact was assessed through comparisons of rotavirus positivity before and after Rotavac was introduced in the national immunization program.
